Home Itens selecionados Provedores de dados OAI Créditos Sobre Ajuda

			Busca avançada
	Provedor de dados BJMBR (2) Autor Guimarães,F.S. (2) Moreira,F.A. (2) Aguiar,D.C. (1) Casarotto,P.C. (1) Crippa,J.A.S. (1) Fogaça,M.V. (1) Gomes,F.V. (1) Hallak,J.E.C. (1) Lisboa,S.F. (1) Zuardi,A.W. (1) Mais... Palavra-chave Anandamide (1) Antipsychotic (1) Anxiety (1) Cannabidiol (1) Cannabinoid (1) D9-Tetrahydrocannabinol (1) Endocannabinoid (1) Endovanilloid (1) Nitric oxide (1) Schizophrenia (1) TRPV1 (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2006 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug BJMBR Zuardi,A.W.; Crippa,J.A.S.; Hallak,J.E.C.; Moreira,F.A.; Guimarães,F.S.. A high dose of delta9-tetrahydrocannabinol, the main Cannabis sativa (cannabis) component, induces anxiety and psychotic-like symptoms in healthy volunteers. These effects of delta9-tetrahydrocannabinol are significantly reduced by cannabidiol (CBD), a cannabis constituent which is devoid of the typical effects of the plant. This observation led us to suspect that CBD could have anxiolytic and/or antipsychotic actions. Studies in animal models and in healthy volunteers clearly suggest an anxiolytic-like effect of CBD. The antipsychotic-like properties of CBD have been investigated in animal models using behavioral and neurochemical techniques which suggested that CBD has a pharmacological profile similar to that of atypical antipsychotic drugs. The results... Tipo: Info:eu-repo/semantics/article Palavras-chave: Cannabidiol; D9-Tetrahydrocannabinol; Cannabinoid; Anxiety; Antipsychotic; Schizophrenia. Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000400001 Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters BJMBR Fogaça,M.V.; Lisboa,S.F.; Aguiar,D.C.; Moreira,F.A.; Gomes,F.V.; Casarotto,P.C.; Guimarães,F.S.. This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or cannabinoid receptor type 1 (CB1) receptor agonists cause clear anxiolytic responses when injected into this region. The nitrergic and eCB systems can regulate the activity of classical neurotransmitters such as glutamate and γ-aminobutyric acid (GABA) that control PAG activity. We propose that they exert a ‘fine-tuning’ regulatory control of defensive responses in this area. This control, however, is... Tipo: Info:eu-repo/semantics/article Palavras-chave: Endocannabinoid; Anandamide; Nitric oxide; Endovanilloid; TRPV1. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400010 Registros recuperados: 2 Primeira ... 1 ... Última

Empresa Brasileira de Pesquisa Agropecuária - Embrapa Todos os direitos reservados, conforme Lei n° 9.610 Política de Privacidade Área restrita		Embrapa Parque Estação Biológica - PqEB s/n° Brasília, DF - Brasil - CEP 70770-901 Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco